NeuroTalk has an important post on MS wrong  diagnosis.[1]  The list of diseases that can mascarade as MS is extensive.

  • Auto-Immune Diseases
Acute Disseminated Encephalomyelitis (ADEM)

Systemic Lupus Erythematosus (SLE),

Sjögren’s Syndrome,

Myasthenia Gravis
  • Infectious Diseases:
Lyme disease (LD)
Human T-cell lymphotrophic virus-1 (HTLV-1)
  • Vascular:
Central nervous system (CNS) Angitis
Dural Arteriovenous Fistulas
  • Others
B12 Deficiencies

Fact is, an MS diagnosis is the result of a combination of MRI lesions readings , neurologist  clinical exams, spinal taps .


Brain MRI Showing  Multiple Sclerosis [NIH Olivier Commowick  (2)]

Keep in mind that the brain lesions seen on MRI are not specific enough by themselves [3,4]

“… MRI evidence plays a supportive role in what is ultimately a clinical diagnosis of MS, in the appropriate clinical situation, and always at the exclusion of alternative diagnoses…”[4]

  1. NeuroTalk  ; “Diseases that can mimic MS”
  2. NIH ; “Detection of DTI White Matter Abnormalities in Multiple Sclerosis Patients” ; 2008
  3. Lancet Neurology ; “MRI and the diagnosis of multiple sclerosis: expanding the concept of “no better explanation” ; 2006
  4. Advanced Neurology ; “The role of MRI in the diagnosis of multiple sclerosis.”;  2006

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