For the folks who want to know if their antioxidant supplementation is doing what it ought to, there are several ways to measure the oxidation level of the lipids in your blood. For that purpose, there are some chemical reactions that tell the tale. They occur when “assays”, or chemical analysis, are run on your blood, or even on breath condensate.
The most common way to assess the level of oxidation fin your blood is to run an assay of your TBARS
- The TBARS stands for “ThioBarbituric Acid Reactive Substances”, and the TBAR test measures the amount of these in the blood as produced from lipid peroxidation, which indicates the level of oxidative stress in your blood.”
But then again, what is the healthy range for any test result is the real question:
Measurement of TBar levels in healthy and renal stones subjects were published in a study from India. But the tables are not clear about the measurements units, though.
For more details about what TBARS entails you can go to the Wikipedia entry on Malondialdehyde (MDA), which is part of the TBARS assessment. But the best depiction was published in the journasl Clinical Chemistry , as an article on “Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct.”
That article has what we were looking :
“Lipoperoxide concentrations (as MDA) averaged 0.60 (SD 0.13) mumol/L in plasma specimens from 41 healthy persons”
Now you know an estimate of the MDA healthy people should have.
Another type of test to evaluate oxidants levels is the Revelar test measuresthe level of Aldehydes in exhaled breath condensate. Aldehydes are low molecular weight compounds which are also very effective biomarkers of oxidative stress. Aldehydes are the result of an oxygen attack on your body’s phospholipids , a major component of all cell membranes. the company claims that “…TBARS assay measures primarily only one aldehyde, namely malondialdehyde (MDA), a byproduct of the lipid peroxidation of arachidonic acid (an omega-6 fatty acid), and studies using more sophisticated chromatographic methods for analysis have shown that as many as 33 different aldehydes are produced by lipid peroxidation, of which MDA is a very minor component.”
For a general discussion on antioxidants and their supplementation go to our post in in MediNewsDigest
Talk to your (serious) nutritionist!