The study published in RHEUMATOLOGY INTERNATIONAL [1] had the following main points:

  • Study was on sixty premenopausal women diagnosed with fibromyalgia
  • Study was also about the effectiveness of amitriptyline alone and in combination with magnesium citrate
  • Pain intensity, pain threshold, the number of tender points, the tender point index:
  • Serum and erythrocyte magnesium levels were  measured

However, no quantification of the pain reduction given, at least in the study abstract. Only that “ pain decreased significantly”. But “significantly”  often means greater than 30%

 Note: Study also included treatment with amitriptyline, a tricyclic antidepressant, and claimed that adding amitriptyline to the magnesium citrate was even more beneficial:

“… The combined amitriptyline + magnesium citrate treatment proved effective on all parameters except numbness…The magnesium citrate treatment was only effective tender points and the intensity of fibromyalgia. ..”

Well,  magnesium citrate certainly does not have the side effects of amitriptyline: {2]

“”...The main two side effects that occur from taking amitriptyline are drowsiness and a dry mouth. Other common side effects of using amitriptyline are mostly due to its anticholinergic activity, including: weight gain, changes in appetite, muscle stiffness, nausea, constipation, nervousness, dizziness, blurred vision, urinary retention, insomnia and changes in sexual function. Some rare side effects include seizures, tinnitus, hypotension, mania, psychosis, sleep paralysis, hypnagogic or hypnopompic hallucinations related to sleep paralysis, heart block, arrhythmias, lip and mouth ulcers, extrapyramidal symptoms,depression, tingling pain or numbness in the feet or hands, yellowing of the eyes or skin, pain or difficulty passing urine, confusion, abnormal production of milk in females, breast enlargement in both males and females, fever with increased sweating, and suicidal thoughts…

Excuse me if the benefits of magnesium citrate seems good enough….

Talk to your Doctor

Conclusions: Low magnesium levels in the erythrocyte[ red blood cells] might be an etiologic factor on fibromyalgia symptoms.

Sources :

  1. Rheumatology International ;“Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia? “;  December 2011
  2. Wikipedia / amitriptyline 
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