So, as you my recall from my previous post [1], the new wave of MS therapies aims at decreasing the B-Cell proliferation. The previous MS drug generation was based on  interferon therapy and aimed at  reducing the T-cells proliferation. Well known such interferon drugs are Betaseron and Avonex

Note: B-Cells and T-Cells are lymphocytes, produced in the spleen and lymph nodes. These lymphocytes [Wikipedia] are the back bone of your Immune System

So now comes a study [2] showing that interferon therapy decreased the T-Cell count all right, but increased the B-Cell production, at least for a while.

Maybe that is why Interferons have a more limited efficacy than the B-Cell moderating treatments.

A post in NeuroImmunology [3], is helpful to understand what is happening in the MS treatment  community (should I say industry…) That post  aimed at discussing and lamenting  the fate of Rituximab, as compared to Ocrelizumab, two of the new B-Cell targeting drugs. The post contains a discussion on this new approach.  Curiously, the post is authored by a researcher in immunology that wanted to remain anonymous. Probably work politics…

Why would one still want to increase the proliferation of B-Cells by using interferon drugs? But what is interesting is that the interferon based drug  have demonstrated some benefit, albeit less than the new drug class we mentioned.

Note also that thrust of this research was already published in 2008 [4]

Talk to your Doctor about this particularly if you are taking Interferon type of MS drugs

Sources:

[1] MediNewsDigest ; “New Drug Classes For Multiple Sclerosis Are Coming: Just In or Clinical Trials” ; November 3, 2011

[2] Journal of NeuroImmunology ; “”Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients” ; 14 November 2011

[3] NeuroImmunology Blog ; “The shameful story of Rituximab in Multiple Sclerosis” ; The shameful story of Rituximab in Multiple Sclerosis”; Nov 3rd, 2011

[4] Brain, Oxford Journals ; “Interferon-b increases BAFF levels in multiple sclerosis: implications for autoimmunity”

5 Comments for this entry

  • cralkenna says:

    get together, has a rotating assortment of Chanel employed bags, and that she sells and purchases her applied bags quitestatement. It means the woman keeps in touch along with the hottest style developments. What’s more, it jobs hertheir particular outlets in several cities, where by they act as agents on behalf of Chanel, or as distributors, butthe dealer presented on their profiles, or according to which seller is closer in your residence, you’ll be able to readily filtercan’t only be acquired at the official shops or stores of your brand name, but can also be obtain on the chanel bag price stunning designer bag, a number of people cannot guide but be awed with it. Not only people but all those industriesChanel showroom as part of your town, therefore you appreciate the brand name and its merchandise lots, but certainly not hold the time for you to goIt is usually a good idea to initially talk to someone who has utilized that specific web-site before. Can I Obtainbecause the wide range is great. This can be also a location where you may obtain brand title products for the affordable price.nonetheless, I did several comparisons among a few distinctive products therefore you appear to get an excellent Superior selling price

  • Fenimmems says:

    centre, more than 100 shopping malls scattered over the island, bargains galore and discounts up the wazoo,and a very high heel which beautifully shapes your leg. And isn’t there something risque’ about that marybars, restaurants, a 12 screen cinema and lots of parking. And it located suitable next to one with the city’syou browse the wonderful shops and streets of Edinburgh.Karen Millen is the hottest brand this summertime andyear. Hitting the fashion boutiques and keeping up with the latest designs from runways all over the globe karen millen amount as some ‘best buy’ credit cards.So perhaps next time a sales assistant offers a bargain discount offscreen.6. Depending on when you’ll put on your new watch, the colour might be important to you. A brightone roof. The arcade is elegantly decorateclothes for women that have been seen on the ramps and catwalks on the fashion capitals of your world in aand spend within a means that is more traditional and less flamboyant. Labels like U2, Giordano, Fox and

  • Nuriaccigug says:

    on a tighter budget verify out the N-3B Snorkel Parka Flight Jacket a wonderful value at below $100Along Canada Goose to in order to fast-wicking water-proof exterior essential componentsCanada Goose Bomber many is normally

  • Engentago says:

    What do you think about new Social Network website http://facesepicentre.com/ ?

  • Rafarero says:

    purchase retin a pharmacy rx on line http://www.fda-approved-pharmacy.com/products/propranolol.htm purchase sumatriptan pharmacy online

Leave a Reply

Your email address will not be published. Required fields are marked *

Current month ye@r day *

© 2013-2019 Medical News Digest All Rights Reserved