MND: We have posted before on plasmapheresis: “Multiple Sclerosis:Blood Plasma Exchange [Plasmapheresis] Backed by AAN for Relapsing/Remitting MS “. In plasmapheresis , the hope is to “.. remove the circulating antibodies that are thought to be responsible for these diseases …” The above post quoted a very important paper on plasma exchange discussing how this was used after an autologous hemopoietic stem cell transplantation (HCST ) transplantation which went wrong.
MND: Blood stem cell transplantation, HSCT to be precise is very different from plasmapheresis. The purpose of HSCT is to introduce new stem cell in the blood of a patient. In stem cell transplantation, the hope is to replace MS damaged T cells by healthy ones .
- Background : Wikipedia has a good entry on HSCT. Click Here for link to Wikipedia
MND: Some success has been reported with HCST:
- In “….Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life…”
However, recent studies shows mixed results
- small scale study [Published in Journal Watch Neurology March 21, 2011] , : Click Here for link to article:
Quoting: “stem cell transplants as performed at this center do not appear to be a cure for MS, as only 25% of patients had stabilized after 15 years. Morbidity and mortality remain ongoing concerns,….”
- Another study has similar conclusions: “Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis.”
Quoting: “Our data parallel results from some of the clinical phase I/II studies showing continued clinical disease progression in multiple sclerosis patients with high expanded disability system scores despite autologous stem cell transplantation.
- The article we quoted before [ “Plasma exchange after hematopoietic stem cell transplantation“ outlines some of the risks of the HCST procedure and how blood plasma echange was called to the rescue….
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