Category Archives: Inflammation

IN BRIEF: FDA Just Approved Oral Relapsing Multiple Sclerosis Drug Aubagio

IN BRIEF: FDA Just Approved Oral Relapsing Multiple Sclerosis Drug Aubagio

Teriflunomide (Aubagio, Genzyme/Sanofi) is coming into the MS market [1]. It is an oral drug, nice. Efficacy:  “30% lower than the rate for those taking a placebo,” said Russell Katz, MD,”   What does that mean? Maybe not as clear as just a percent reduction in releases, think compounding. Sagepub …Read the Rest

IN DEPTH: Multiple Sclerosis Research And The Blood Brain Barrier

IN DEPTH: Multiple Sclerosis Research And The Blood Brain Barrier

The Blood Brain Barrier (BBB) is a main focus of Multiple Sclerosis research.  There are currently two main directions for that research: Control of the entry into  the brain of the immune system T-cell crossing through the impaired BBB Sending drugs into the brain directly by overriding the BBB An …Read the Rest

MND BRIEF: Study Shows Multiple Sclerosis Burns Up Vitamin D, But Do Vitamin D supplements fight MS?

MND BRIEF: Study Shows Multiple Sclerosis Burns Up Vitamin D, But Do Vitamin D supplements fight MS?

  A study shows that Multiple Sclerosis (MS) treatment by Interferon-Beta  improves  the ability of the MS patient to produce vitamin D by exposure of their skin to the sun The research was done at the Australian facility  Menzies Research Institute Tasmania Quoting the article [1]: “…In this study, we found …Read the Rest

MND BRIEF: Multiple Sclerosis: Beta interferons (β-IFNs) might not slow disability progression

MND BRIEF: Multiple Sclerosis: Beta interferons (β-IFNs) might not slow disability progression

A new study by the University of British Columbia casts doubt on the benefits of the Interferon treatment against Relapsing-Remitting Multiple Sclerosis Here is the YouTube video from the press release The video tries to mitigate the setback with warm fuzzy statements about future research, but the tone of the …Read the Rest

IN DEPTH: Is There A Role For Nutraceuticals In Heart Disease?

IN DEPTH: Is There A Role For Nutraceuticals In Heart Disease?

Heart disease falls  into several classes: Coronary disease is the most frequent [1], but valvular [2] is not far behind: Who doesn’t have a relative or friend who had some heart valve replaced or bypass surgery? Actually [2] is giving epidemiology statistics: “…Aortic valve sclerosis (aortic valve thickening and calcification) seem …Read the Rest

IN DEPTH: About Heart Risks, Calcium, and Food Fortification

IN DEPTH: About Heart Risks, Calcium, and Food Fortification

All right, what are the foods and food  supplements that are touted as beneficial for your heart? Easy: Vitamins: E , B complex, D, K Compounds and polyphenols: CoEnzymeQ10, Resveratrol, Flavonol, Soy  Minerals: Selenium, magnesium and many more… We posted in MND [1] on such and other nutrients reputed to be good …Read the Rest

New Drug Delivery:  Nanoparticles Remotely Activated To Release Protein Producing DNA To Fight Disease

New Drug Delivery: Nanoparticles Remotely Activated To Release Protein Producing DNA To Fight Disease

This is not just about a new method of drug delivery, rather it is about a new class of treatments that may be possible because of this new drug delivery technique. This work was carried on by a rather large research group from  several Canadian and US institutions [1] : …Read the Rest

Possible New Treatment of Progressive Multiple Sclerosis: Masitinib

Possible New Treatment of Progressive Multiple Sclerosis: Masitinib

There are few treatments efficacious for the Progressive Forms of Multiple Sclerosis (PPMS and SPMS).  Most of the current treatment consists of anti-inflammatory disease modifying drugs that attempt to re-educate an mistaken immune system. They attack the Relapsing-remitting form of MS Here is a summary of the arsenal: Interferons (all …Read the Rest

Severe Crohn’s Disease In Children: Feeding Tube (Bypassing Normal GI Route)  For Two months  Shown To Be as Efficacious as Corticosteroids

Severe Crohn’s Disease In Children: Feeding Tube (Bypassing Normal GI Route) For Two months Shown To Be as Efficacious as Corticosteroids

For children with  severe cases of Crohn’s disease ,  corticosteroids and disease modifying drugs are often used, since it is an inflammatory auto-immune disease. An other possible approach is enteral  feeding through a feeding tube,  technically called Exclusive Enteral Nutrition (EEN). The treatment has been found to be as efficacious as corticosteroids …Read the Rest

In Brief: High Doses of Vitamin D Not Very Helpful in Treating Multiple Sclerosis

In Brief: High Doses of Vitamin D Not Very Helpful in Treating Multiple Sclerosis

High doses not better than low dose in vitamin D2 treatment of RRMS according to astudy published in Neurology[1]. “…No significant treatment differences were detected in the primary MRI endpoints.” That begs the question: What is the efficiency of a low dose treatment? Low dose being usually understood as less …Read the Rest

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